Endocrine Abstracts

Introduction: Pregnancy and lactation associated osteoporosis (PLO) is a rare condition in which women typically present with fractures, often vertebral, in the third trimester of pregnancy or in the early postpartum period. Bone loss of 3–10% at the spine and hip are seen over 3–6 months of lactation. Bone loss is related to duration of lactation and amenorrhea and is not prevented by calcium supplementation.Methods: We studied a woma...

Introduction: Bone loss in thyroid dysfunction was first described by von Recklinghausen. Elevated bone turnover and decreased bone mass result when thyroid hormone levels are high and TSH levels suppressed. The changes in bone mass are impressive even in patients whit subclinical hypertiroidism, where thyroid hormones are within the normal range, but TSH is low or undetectable. Evidence show that endogenous and exogenous TSH suppression is associated with an increased fractur...

Introduction: Oral levothyroxine (L-T4) is the standard treatment for hypothyroidism and serum TSH represents the best marker for assessing the proper L-T4 dose. The absorption and bioequivalence of different commercial L-T4 preparations might be variable. The aim of this study is to compare the efficacy of L-T4 using alternating doses vs fixed ones.Me...

Introduction: Oral levothyroxine (LT4) is the standard treatment for hypothyroidism and serum TSH represents the best marker for assessing the proper LT4 dose. The absorption and bioequivalence of different commercial LT4 preparations might be variable. The aim of this study is to compare the efficacy of levothyroxine oral solution vs tablets.Methods: Fifty-eight patients (six males, 52 females; average age, 46.9±12....